Is Tramadol better than Codeine for pain relief? Tramadol and codeine are both opioid analgesics, but they differ in potency and side effects. Tramadol is considered slightly stronger and has dual action—targeting opioid receptors and inhibiting serotonin and norepinephrine reuptake—making it suitable for moderate to moderately severe pain. Codeine is milder and often combined with acetaminophen. Tramadol may be preferable for longer-term management due to its sustained-release options, while codeine is often used short-term. Side effects and individual response vary.
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